Authors

Title

Citation

1

Shelby, S. M.

Partnering with Clinical CROs - From the Inside Out and the Outside In: An End User Perspective

American Pharmaceutical Outsourcing
4:6;26-32

2

Aboulafia, D. M., Norris, D., Henry, D., Grossman, R. J., Thommes, J., Bundow, D., Yocum, R. C. and Stevens, V.

9-cis-Retinoic Acid Capsules in the Treatment of AIDS-Related Kaposi Sarcoma: Results of a Phase 2 Multicenter Clinical Trial

Archives of Dermatology
139:2;178-186

3

Zhi, L., Tegley, C. M., Pio, B., Edwards, J. P., Jones, T. K., Marschke, K. B., Mais, D. A., Risek, B. and Schrader, W. T.

Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators

Bioorganic & Medicinal Chemistry Letters
13:12;2071-2074

4

Zhi, L., Ringgenberg, J. D., Edwards, J. P., Tegley, C. M., West, S. J., Pio, B., Motamedi, M., Jones, T. K., Marschke, K. B., Mais, D. A. and Schrader, W. T.

Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore

Bioorganic & Medicinal Chemistry Letters
13:12;2075-2078

5

Michellys, P.-Y., Boehm, M. F., Chen, J.-H., Grese, T. A., Karanewsky, D. S., Leibowitz, M. D., Liu, S., Mais, D. A., Mapes, C. M., Reifel-Miller, A., Rungta, D., Ogilvie, K. M., Thompson, A. W., Tyhonas, J. S., Yumibe, N. P. and Ardecky, R. J.

Design and synthesis of novel RXR-selective modulators with improved pharmacological profile

Bioorganic & Medicinal Chemistry Letters
13:22;4071-4075

6

Farmer, L. J., Zhi, L., Jeong, S., Lamph, W. W., Osburn, D. L., Croston, G. E., Flatten, K. S., Heyman, R. A. and Nadzan, A. M.

Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid

Bioorganic & Medicinal Chemistry Letters
13:2;261-264

7

King, C. R. and Khabazian, A.

Avinza® (morphine sulfate extended-release capsules)

Clinical Journal of Oncology Nursing
7:4;458-460, 478

8

Rosen, J., Marschke, K. B. and Rungta, D.

Nuclear hormone receptor assays for drug discovery

Current Opinion in Drug Discovery & Development
6:2;224-230

9

Cohen, K. A., Liu, T., Bissonette, R. P., Puri, R. K. and Frankel, A. E.

DAB(389)EGF Fusion Protein Therapy of Refractory Glioblastoma Multiforme

Current Pharmaceutical Biotechnology
4:1;39-49

10

Polek, T. C., Stewart, L. V., Ryu, E. J., Cohen, M. B., Allegretto, E. A. and Weigel, N. L.

p53 Is Required for 1,25-Dihydroxyvitamin D3-Induced G0 Arrest But Is Not Required for G1 Accumulation or Apoptosis of LNCaP Prostate Cancer Cells

Endocrinology
144:1;50-60

11

Kempf, W., Kettelhack, N., Duvic, M. and Burg, G.

Topical and systemic retinoid therapy for cutaneous T-cell lymphoma

Hematology/Oncology Clinics of North America
17:6;1405-1419

12

Michellys, P.-Y., Ardecky, R. J., Chen, J.-H., Crombie, D. L., Etgen, G. J., Faul, M. M., Faulkner, A., Grese, T. A., Heyman, R. A., Karanewsky, D. S., Klausing, K., Leibowitz, M. D., Liu, S., Mais, D. A., Mapes, C. M., Marschke, K. B., Reifel-Miller, A., Ogilvie, K. M., Rungta, D., Thompson, A. W., Tyhonas, J. S. and Boehm, M. F.

Novel (2E,4E,6Z)-7-(2-Alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic Acid Retinoid X Receptor Modulators Are Active in Models of Type 2 Diabetes

Journal of Medicinal Chemistry
46:13;2683-2696

13

Michellys, P.-Y., Ardecky, R. J., Chen, J.-H., D'Arrigo, J., Grese, T. A., Karanewsky, D. S., Leibowitz, M. D., Liu, S., Mais, D. A., Mapes, C. M., Montrose-Rafizadeh, C., Ogilvie, K. M., Reifel-Miller, A., Rungta, D., Thompson, A. W., Tyhonas, J. S. and Boehm, M. F.

Design, Synthesis, and Structure-Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids

Journal of Medicinal Chemistry
46:19;4087-4103

14

Zhi, L., Tegley, C. M., Pio, B., Edwards, J. P., Motamedi, M., Jones, T. K., Marschke, K. B., Mais, D. E., Risek, B. and Schrader, W. T.

5-Benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as Selective Progesterone Receptor Modulators

Journal of Medicinal Chemistry
46:19;4104-4112

15

Xu, Y., Mayhugh, D., Saeed, A., Wang, X., Thompson, R. C., Dominianni, S. J., Kauffman, R. F., Singh, J., Bean, J. S., Bensch, W. R., Barr, R. J., Osborne, J., Montrose-Rafizadeh, C., Zink, R. W., Yumibe, N. P., Huang, N., Luffer-Atlas, D., Rungta, D., Mais, D. A. and Mantlo, N. B.

Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor alpha Agonist

Journal of Medicinal Chemistry
46:24;5121-5124

16

Kurie, J. M., Lotan, R., Lee, J. J., Lee, J. S., Morice, R. C., Liu, D. D., Xu, X.-C., Khuri, F. R., Ro, J. Y., Hittelman, W. N., Walsh, G. L., Roth, J. A., Minna, J. D. and Hong, W. K.

Treatment of Former Smokers With 9-cis-Retinoic Acid Reverses Loss of Retinoic Acid Receptor- Expression in the Bronchial Epithelium: Results From a Randomized Placebo-Controlled Trial

Journal of the National Cancer Institute
95:3;206-214

17

Tyree, C. M. and Klausing, K. U.

The Mammalian two-hybrid assay for detection of coactivator-nuclear receptor interactions

Journal
85:;175-183

18

Miner, J. N., Tyree, C. M., Hu, J., Berger, E. M., Marschke, K. B., Nakane, M., Coghlan, M. J., Clemm, D. L., Lane, B. C. and Rosen, J.

A nonsteroidal glucocorticoid receptor antagonist

Molecular Endocrinology
17:1;117-127

19

Coghlan, M. J., Jacobson, P. B., Lane, B. C., Nakane, M., Lin, C.-W. W., Elmore, S. W., Kym, P. R., Luly, J. R., Carter, G. W., Turner, R., Tyree, C. M., Hu, J., Elgort, M., Rosen, J. and Miner, J. N.

A novel anti-inflammatory maintains glucocorticoid efficacy with reduced side effects

Molecular Endocrinology
17:5;860-869

20

Marin, R., Guerra, B., Hernandez-Jimenez, J. G., Kang, X. L., Fraser, J. D., Lopez, F. J. and Alonso, R.

Estradiol prevents amyloid-beta peptide-induced cell death in a cholinergic cell line via modulation of a classical estrogen receptor

Neuroscience
121:4;917-26

21

Hernandez, G., Hernandez-Jimenez, J. G., Guelmes, P., Sanchez-Criado, J. E., Bellido, C., Martinez-Morales, J. R., Prieto, L., Marin, F., Glidewell-Kenney, C., Lopez, F. J. and Alonso, R.

Effect of treatment with the selective oestrogen receptor modulator LY117018-HCl on pituitary sensitivity to GnRH and subsequent ovulation

Reproduction
125:4;597-606

     Authors

Title

Citation

1

Kim, H. T., Kong, G., Denardo, D., Pal, S., Duong, S., Hilsenbeck, S. G., Bissonnette, R. P., Lamph, W. W., Johnson, K. and Brown, P. H.

Identification of genes regulated by the RXR-selective retinoid, LGD1069, in human breast cells using oligonucleotide arrays

25th Annual San Antonio Breast Cancer Symposium
76:Supplement 1;S58

2

McDonnell, D. P., Wijayaratne, A., Chang, C.-y. and Norris, J. D.

Elucidation of the molecular mechanism of action of selective estrogen receptor modulators

American Journal of Cardiology
90:1;F35-F43

3

Breneman, D. L., Duvic, M., Kuzel, T., Yocum, R., Truglia, J. A. and Stevens, V. J.

Phase 1 and 2 trial of bexarotene gel for skin-directed treatment of patients with cutaneous T-cell lymphoma

Archives of Dermatology
138:3;325-332

4

Miner, J. N.

Designer glucocorticoids

Biochemical Pharmacology
64:3;355-361

5

Wrobel, J., Green, D., Jetter, J., Kao, W., Rogers, J., Perez, M. C., Hardenburg, J. L., Deecher, D. C., Lopez, F. J., Arey, B. J. and Shen, E. S.

Synthesis of (bis)sulfonic acid, (bis)benzamides as follicle-stimulating hormone (FSH) antagonists

Bioorganic and Medicinal Chemistry
10:3;639-656

6

Nowfar, S., Teplitzky, S. R., Melancon, K., Kiefer, T. L., Cheng, Q., Dwivedi, P. D., Bischoff, E. D., Moroz, K., Anderson, M. B., Dai, J., Lai, L., Yuan, L. and Hill, S. M.

Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin

Breast Cancer Research and Treatment
72:1;33-43

7

Kim, H. T., Kong, G., Denardo, D., Pal, S., Duong, S., Hilsenbeck, S. G., Bissonnette, R. P., Lamph, W. W., Johnson, K. and Brown, P. H.

Identification of genes regulated by the RXR-selective retinoid, LGD1069, in human breast cells using oligonucleotide arrays

Breast Cancer Research and Treatment
76:Supplement 1;S58

8

Pettersson, F., Dalgleish, A. G., Bissonnette, R. P. and Colston, K. W.

Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax

British Journal of Cancer
87:5;555-561

9

Wu, K., Kim, H. T., Rodriquez, J. L., Hilsenbeck, S. G., Mohsin, S. K., Xu, X.-C., Lamph, W. W., Kuhn, J. G., Green, J. E. and Brown, P. H.

Suppression of mammary tumorigenesis in transgenic mice by the RXR- selective retinoid, LGD1069

Cancer Epidemiology Biomarkers & Prevention
11:5;467-474

10

Wu, K., Zhang, Y., Xu, X.-C., Hill, J., Celestino, J. C., Kim, H. T., Mohsin, S. K., Hilsenbeck, S. G., Lamph, W. W., Bissonette, R. P. and Brown, P. H.

The Retinoid X Receptor-Selective Retinoid, LGD1069, Prevents the Development of Estrogen Receptor-Negative Mammary Tumors in Transgenic Mice

Cancer Research
62:22;6376-6380

11

Suh, N., Lamph, W. W., Glasebrook, A. L., Grese, T. A., Palkowitz, A. D., Williams, C. R., Risingsong, R., Farris, M. R., Heyman, R. A. and Sporn, M. B.

Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268

Clinical Cancer Research
8:10;3270-3275

12

Eliot, L., Butler, J., Devane, J. and Loewen, G.

Pharmacokinetic evaluation of a sprinkle-dose regimen of a once-daily, extended-release morphine formulation

Clinical Therapeutics
24:2;260-268

13

Rosen, J. and Miner, J. N.

Improving the Utility of Steroidal Anti-Inflammatories: Identification of Selective Glucocorticoid Receptor Modulators

Current Medicinal Chemistry: Immunology, Endocrine & Metabolic Agents
2:1;11-22

14

Etgen, G. J., Oldham, B. A., Johnson, W. T., Broderick, C. L., Montrose, C. R., Brozinick, J. T., Misener, E. A., Bean, J. S., Bensch, W. R., Brooks, D. A., Shuker, A. J., Rito, C. J., McCarthy, J. R., Ardecky, R. J., Tyhonas, J. S., Dana, S. L., Bilakovics, J. M., Paterniti, J. R., Jr., Ogilvie, K. M., Liu, S. and Kauffman, R. F.

A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-alpha/gamma agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models

Diabetes
51:4;1083-1087.

15

Ortiz, M., Bayon, Y., Lopez-Hernandez, F. and Piedrafita, F. J.

Retinoids in combination therapies for the treatment of cancer: mechanisms and perspectives

Drug Resistance Updates
5:3-4;162

16

Arey, B. J., Deecher, D. C., Shen, E. S., Stevis, P. E., Meade, E. H., Jr., Wrobel, J., Frail, D. E. and Lopez, F. J.

Identification and characterization of a selective, nonpeptide follicle-stimulating hormone receptor antagonist

Endocrinology
143:10;3822-3829

17

Liu, S., Ogilvie, K. M., Klausing, K., Lawson, M. A., Jolley, D., Li, D., Bilakovics, J. M., Pascual, B., Hein, N., Urcan, M. and Leibowitz, M. D.

Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat

Endocrinology
143:8;2880-2885

18

Eliot, L., Cato III, A., Geiser, R. and Loewen, G. P.

Evaluation of Two Loading-Dose Regimens of Morphelan (TM) in Healthy Volunteers

Journal of Applied Research: in clinical and experimental therapeutics
2:1;1-8

19

van de Merbel, N. C., van Veen, J. H., Wilkens, G. and Loewen, G. P.

Validated liquid chromatographic method for the determination of bexarotene in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
775:2;189-195

20

Poast, J., Seidel, H. M., Hendricks, M. D., Haslam, J. A., Levy, H. B. and Baron, S.

Poly I : CLC induction of the interferon system in mice: An initial study of four detection methods

Journal of Interferon and Cytokine Research
22:10;1035-1040

21

Guitart, J., Tucker, R. and Stevens, V.

Low dose bexarotene (Targretin (R)) capsules and phototherapy for early stage cutaneous T-cell lymphoma

Journal of Investigative Dermatology
119:1;199

22

Duffy, K. J., Shaw, A. N., Delorme, E. O., Dillon, S. B., Erickson-Miller, C., Giampa, L., Huang, Y., Keenan, R. M., Lamb, P., Liu, N., Miller, S. G., Price, A. T., Rosen, J., Smith, H., Wiggall, K. J., Zhang, L. and Luengo, J. I.

Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics

Journal of Medicinal Chemistry
45:17;3573-3575

23

Duffy, K. J., Price, A. T., Delorme, E. O., Dillon, S. B., Duquenne, C., Erickson-Miller, C., Giampa, L., Huang, Y., Keenan, R. M., Lamb, P., Liu, N., Miller, S. G., Rosen, J., Shaw, A. N., Smith, H., Wiggall, K. J., Zhang, L. and Luengo, J. I.

Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 2. Rational Design of Naphtho[1,2-d]imidazole Thrombopoietin Mimics

Journal of Medicinal Chemistry
45:17;3576-3578

24

Zhang, P., Terefenko, E. A., Fensome, A., Wrobel, J., Winneker, R., Lundeen, S., Marschke, K. B. and Zhang, Z.

6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones: A Novel Class of Potent, Selective, and Orally Active Nonsteroidal Progesterone Receptor Antagonists

Journal of Medicinal Chemistry
45:20;4379-4382

25

Rosen, J. and Negro-Vilar, A.

Novel, non-steroidal, selective androgen receptor modulators (SARMs) with anabolic activity in bone and muscle and improved safety profile

Journal of Musculoskeltal and Neuronal Interactions
2:3;222-224

26

Eliot, L., Geiser, R. and Loewen, G.

Steady-state pharmacokinetic comparison of a new, once-daily, extended-release morphine formulation (MorphelanTM) and OxyContinR twice daily

Journal of Oncology Pharmacy Practice
7:1;1-8

27

Caldwell, J. R., Rapoport, R. J., Davis, J. C., Offenberg, H. L., Marker, H. W., Roth, S. H., Yuan, W., Eliot, L., Babul, N. and Lynch, P. M.

Efficacy and safety of a once-daily morphine formulation in chronic, moderate-to-severe osteoarthritis pain: results from a randomized, placebo-controlled, double-blind trial and an open-label extension trial

Journal of Pain and Symptom Management
23:4;278-291

28

Portenoy, R. K., Sciberras, A., Eliot, L., Loewen, G. P., Butler, J. and Devane, J.

Steady-state pharmacokinetic comparison of a new, extended-release, once-daily morphine formulation, Avinza, and a twice-daily controlled-release morphine formulation in patients with chronic moderate-to-severe pain

Journal of Pain and Symptom Management
23:4;292-300

29

Tyree, C. M., Zou, A. and Allegretto, E. A.

17beta-Estradiol inhibits cytokine induction of the human E-selectin promoter

Journal of Steroid Biochemistry and Molecular Biology
80:3;291-297

30

Lin, C. W., Nakane, M., Stashko, M., Falls, D., Kuk, J., Miller, L., Huang, R., Tyree, C. M., Miner, J. N., Rosen, J., Kym, P. R., Coghlan, M. J., Carter, G. and Lane, B. C.

Trans-activation and repression properties of the novel nonsteroid glucocorticoid receptor ligand 2,5-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-(1-methylcyclohexen-3-y1)-1H

Molecular Pharmacology
62:2;297-303

31

Deecher, D. C. and Lopez, F. J.

Discrimination of galanin receptor subtypes in RINm5F cells by structurally different galanin radioligands

Peptides
23:3;545-553

32

Michellys, P.-Y., Maurin, P., Pellissier, H. and Santelli, M.

Allylsilane addition on C-13 of 11-methoxycarbonyl-17-acetyl-1,3,5(10),13(17)-gonatetraenes: a straightforward route to introduce an 18[alpha] -methyl group

Tetrahedron Letters
43:;4339-4342