Press Releases

Ligand to Hold Fourth Quarter Results Conference Call on February 20

SAN DIEGO--

Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) announced today that it plans to report fourth quarter 2007 financial results on Wednesday, February 20, 2008 following the close of market. Ligand's President and CEO, John L. Higgins, Vice President of Finance and CFO, John P. Sharp and Vice President of Discovery Research, Martin Meglasson will host the conference call.

What:            Ligand Pharmaceuticals conference call to discuss
                  financial results and provide general business
                  updates.

When:            Wednesday, February 20, 2008

Time:            1:30 p.m. Pacific time (4:30 p.m. Eastern time)

Webcast:         Conference call and replay accessible at
                  www.ligand.com.

Conference Call: (877) 356-5578, ID # 33354833 (U.S.)
                 (706) 679-0565, ID # 33354833 (outside the U.S.)

Replay:          (800) 642-1687, ID # 33354833 (U.S.)
                 (706) 645-9291, ID # 33354833 (outside the U.S.)
                 Replay of conference call will be available from
                  February 20, 2008 to March 20, 2008.

About Ligand Pharmaceuticals

Ligand discovers and develops new drugs that address critical unmet medical needs of patients in the areas of thrombocytopenia, hepatitis C, cancer, hormone-related diseases, osteoporosis and inflammatory diseases. Ligand's proprietary drug discovery and development programs are based on its leadership position in gene transcription technology, primarily related to intracellular receptors.

Source: Ligand Pharmaceuticals Incorporated