LTP Technology

Liver Targeting Prodrug (LTP) Technology

Ligand’s LTP TECHNOLOGY™ is a broad second generation liver-targeting prodrug technology that has an activation mechanism similar to HepDirect™ but with broader applications and many improved features. The proprietary chemical modifications can be used with many chemical classes of drugs in addition to phosphorus-containing compounds and have multiple chemistry strategies, improving flexibility and success rates.  In addition, the second generation technology eliminates the undesirable by-products released during activation of the first generation prodrugs.