Licensing Opportunities

Multiple Technologies and Programs Available for Out-License

Ligand currently has multiple unpartnered programs available for out-licensing in addition to our Captisol, OmniAb, LTP and HepDirect technologies which are available to partners that could benefit from formulation, antibody discovery or other early stage drug targeting and development expertise.

Licensing Opportunities To discuss licensing opportunities, please contact our Business Development Team

Captisol-enabled™ Iohexol

Summary

Ligand is developing a novel Captisol® formulation of Iohexol for use as a contrast agent used during diagnostic imaging procedures.

More about this opportunity »

Granulocyte Colony Stimulating Factor (GCSF)

Summary

Granulocyte colony stimulating factor (GCSF) acts on its receptor to stimulate the differentiation of bone marrow hematopoietic cells to form neutrophils.

More about this opportunity »

Captisol Enabled™ Busulfan

Summary

Ligand is developing a novel Captisol® formulation of Busulfan for use as a conditioning agent prior to hematopoietic stem cell transplantation.

More about this opportunity »

Captisol-enabled™ Sertraline, Oral Concentrate

Summary

Captisol-enabled® Sertraline (LGD-953) is designed to be the potential first aqueous oral solution to meet the growing demand for better liquid antidepressants for elderly and pediatric patients who are the least able to ingest pills.

More about this opportunity »

Captisol-enabled™ Cetirizine Injection

Summary

Ligand is developing a Captisol-enabled™ injectable formulation of the antihistamine cetirizine to provide rapid onset to treat acute, life-threatening, allergy symptoms.

More about this opportunity »

Captisol-enabled™ Silymarin for Topical Formulation

Summary

Ligand is developing novel Captisol-enabled™ silymarin composition for application in the topical sun damage and anti‐aging premium skin-care markets. 

More about this opportunity »

FLT3 Kinase Inhibitors

Summary

FMS-like tyrosine kinase-3 (FLT3) is a receptor tyrosine kinase with an important role in hematopoietic progenitor cell development.

More about this opportunity »

Liver-Specific Glucokinase Program

Summary

Glucokinase (GKA) is an enzyme that facilitates removal of glucose in circulation and functions as a glucose sensor mainly in the liver and pancreas cells.

More about this opportunity »

CCR1

Summary

Chemokine receptor 1 (CCR1) is a receptor on the surface of various immune cells (e.g. monocytes and T-cells) that bind multiple chemokines and directly mediates inflammatory responses through leukocyte chemotaxis and cytokine balance.

More about this opportunity »

Nav1.9

Summary

The voltage-gated sodium channel Nav1.9 is primarily expressed in nociceptive and myenteric neurons and plays a key role in the transmission and regulation of pain sensation. Modulation of Nav1.9 function represents a novel pain drug discovery strategy that should avoid the limitations of opioid based pain therapies.

More about this opportunity »

BCAT

Summary

The Branched Chain Amino Acid Transferase (BCAT2) enzyme is expressed in mitochondria and is responsible for the initial step in the metabolism branched chain amino acid (BCAA) such as valine, leucine and isoleucine. Aberrant levels of BCAA metabolites are implicated in the development of cardiometabolic diseases as well as diseases caused by inborn errors of metabolism.

More about this opportunity »

cGAS

Summary

Cyclic GMP-AMP synthase (cGAS) is a cytosolic double-stranded DNA sensor that activates a Type I interferon response. cGAS is a component of the innate immune system protecting against DNA viral infection as well as certain retroviruses. Aberrant cGAS activity can lead to autoimmune disorders as well as rare neurodevelopmental encephalopathies.

More about this opportunity »

GYS

Summary

Glycogen Synthase is a key enzyme in the glycogenesis pathway and produces glycogen, a key cellular fuel in humans. Deficits in glycogen clearance lead to several disorders including inborn errors of metabolism such as Pompe disease.

More about this opportunity »

Nav1.1

Summary

The neuronal voltage-gated sodium channel Nav1.1 plays an important role in regulating central nervous system excitability. Loss of function mutations of the human Nav1.1 gene leads to increased neuronal excitability which results in debilitating seizure disorders such as Dravet Syndrome and Generalized Epilepsy with Febrile Seizures Plus.

More about this opportunity »

ApoL1

Summary

ApoL1 is a protein involved in the innate immune system providing protection from trypanosome infections leading to African Sleeping Sickness. Genetic variants of ApoL1 that provide enhanced trypanosome immunity have been linked to a significantly increased risk of developing Chronic Kidney Disease and End Stage Renal Disease in African populations and populations with recent African ancestry, including African Americans.

More about this opportunity »